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Most tobacco products, including e cigarettes, contain nicotine, a chemical that can harm the heart, brain and whole body. As with other addictive products, using a nicotine product builds tolerance, leading to more Correlation between smokeless tobacco (Gutkha) and biomarkers of oxidative stress in plasma with cardiovascular effects ScienceDirect smokeless tobacco cholesterol Just because it's not smoked doesn't mean it's safe. Chewing tobacco still exposes you to dangerous health risks like Tobacco's Hidden Harm: How It Damages Your Heart, Brain and Skin Max Hospital Health effects of smoking tobacco Wikipedia

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